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[3] [40] Oral micronized estradiol consists of more than 80% of estradiol particles micronized to a size smaller than 20 μm in diameter, or to about 1 to 3 μm on average. [41] [42] [40] [43] All oral formulations of estradiol available today are micronized, [36] and oral estradiol valerate tablets also seem to be micronized. [44]
The metabolic clearance rate of a steroid is defined as the volume of blood that has been completely cleared of the hormone per unit time. The production rate of a steroid hormone refers to entry into the blood of the compound from all possible sources, including secretion from glands and conversion of prohormones into the steroid of interest ...
Clearance of a substance is sometimes expressed as the inverse of the time constant that describes its removal rate from the body divided by its volume of distribution (or total body water). In steady-state, it is defined as the mass generation rate of a substance (which equals the mass removal rate) divided by its concentration in the blood .
In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body. [2]
An equianalgesic chart is a conversion chart that lists equivalent doses ... Comparison to oral morphine [a] Analgesic ... 1,000–3,000 3.3–10 μg Ohmefentanyl ...
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