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Subcutaneous injection sites. Commonly used injection sites include: [3]: 723 The outer area of the upper arm. The abdomen, avoiding a 2-inch circle around the navel. The front of the thigh, between 4 inches from the top of the thigh and 4 inches above the knee. The upper back. The upper area of the buttock, just behind the hip bone.
[8] [12] [13] [14] Elranatamab is given by subcutaneous injection. [ 8 ] [ 12 ] The most common side effects include cytokine release syndrome , fatigue , injection site reaction , diarrhea , upper respiratory tract infection , musculoskeletal pain , pneumonia , decreased appetite , rash , cough , nausea , and pyrexia (fever).
After subcutaneous injection, the erenumab has an estimated bioavailability of 82%. Highest blood plasma concentrations are reached after four to six days. Like other proteins, the substance is degraded by proteolysis to small peptides and amino acids. It has an elimination half-life of 28 days. [9]
Subcutaneous (under the skin). [22] This generally takes the form of subcutaneous injection, e.g. with insulin. Skin popping is a slang term that includes subcutaneous injection, and is usually used in association with recreational drugs. In addition to injection, it is also possible to slowly infuse fluids subcutaneously in the form of ...
Fremanezumab, sold under the brand name Ajovy, is a medication used to prevent migraines in adults. [8] [6] It is given by injection under the skin. [8] [6] The most common side effect is pain and redness at the site of injection. [8] Other side effects include allergic reactions. [8]
Injection site reactions such as redness and pain are common, occurring in approximately 11.4% of cases. [21] Dupilumab can cause allergic reactions, conjunctivitis, and keratitis and, due to its immunosuppressive effects, reactivation of cold sores. [7] In clinical trials, people receiving dupilumab had decreased levels of T helper cells. [22]
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Canakinumab, sold under the brand name Ilaris, is a medication for the treatment of systemic juvenile idiopathic arthritis, active Still's disease, including adult-onset Still's disease, gout flares. [ 4 ] [ 5 ] [ 6 ] It is a human monoclonal antibody targeted at interleukin-1 beta .