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Extracts from Camptotheca (the "happy tree" or "cancer tree") were used to develop the chemotherapeutic drug Topotecan. Plant sources of anti-cancer agents are plants, the derivatives of which have been shown to be usable for the treatment or prevention of cancer in humans. [1] [2]
Camptothecin (CPT) is a topoisomerase inhibitor.It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs.It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used in traditional Chinese medicine.
The Madagascan periwinkle Catharanthus roseus L. is the source for a number of important natural products, [1] including catharanthine and vindoline [2] and the vinca alkaloids it produces from them: leurosine and the chemotherapy agents vinblastine [3] and vincristine, [4] all of which can be obtained from the plant.
Azadiradione acts as an antioxidant and has been used in traditional medicine in Asia, Africa and the Middle East for ages. [1]Research suggests azadiradione may have properties that fight microbes (bacteria, fungi, viruses), [2] reduce inflammation, protect cells from damage, [3] and even have anti-cancer effects.
The extracts and purified platycoside compounds from the roots may exhibit neuroprotective, antimicrobial, anti-inflammatory, anti-cancer, anti-allergy, improved insulin resistance, and cholesterol-lowering properties. [121] Polemonium reptans: Abscess root It is used to reduce fever, inflammation, and cough. [122] Psidium guajava: Guava
The journal covers developments in "medicinal chemistry and rational drug design for the discovery of anti-cancer agents" and publishes original research reports and review papers. [1] It is related to the journal Current Medicinal Chemistry and was established in 2001 as Current Medicinal Chemistry – Anti-Cancer Agents. [2]
The plants collection project was part of the many expeditions launched by United States National Cancer Institute (NCI), to find new natural substances to treat cancer and AIDS infection. In September 1987, a botanist named John Burley went on a mission to collect plant samples from a swamp forest at Lundu, Sarawak, Malaysia.
Agents that disrupt microtubules therefore inhibit mitosis through activation of this checkpoint. [11] Moroidin and its related compounds, the celogentins, inhibit tubulin polymerization. Of this family, celogentin C is the most potent (IC 50 0.8×10 −6 M), and it is more potent than the anti-mitotic agent vinblastine (IC 50 3.0×10 −6).