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Atypical depression is a chronic syndrome that tends to begin earlier in life than other forms of depression—usually beginning in the teenage years. Similarly, patients with atypical depression are more likely to have anxiety disorders, (such as generalized anxiety disorder, obsessive–compulsive disorder, and social anxiety disorder ...
The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...
The first-line antibiotics for treatment of Chlamydia pneumoniae are the macrolide erythromycin and the tetracyclines tetracycline and doxycycline. [39] The macrolides clarithromycin and azithromycin are also effective. [39] Chlamydia pneumoniae shows resistance to penicillin, ampicillin, and sulfa drugs, and hence these antibiotics are not ...
Medium- (7–12 months) and long‐term (longer than 12 months) effects seem similarly beneficial. Psychological therapies, including cognitive behavioral therapy, added to usual care (antidepressants) seem as acceptable as usual care alone and may be used as a first line treatment for mild to moderate treatment resistant depression. [41] [23]
Newer MAOIs such as selegiline (typically used in the treatment of Parkinson's disease) and the reversible MAOI moclobemide provide a safer alternative [19] and are now sometimes used as first-line therapy. Pargyline is a non-selective MAOI that was previously used as an antihypertensive agent to treat hypertension (high blood pressure). [21] [22]
Patients with depressive symptomology characterized as "atypical," "nonendogenous," and/or "neurotic" respond particularly well to phenelzine. [7] The medication is also useful in patients who do not respond favorably to first and second-line treatments for depression, or are " treatment-resistant ."