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For genotype 1 hepatitis C treated with pegylated interferon-alfa-2a or pegylated interferon-alfa-2b combined with ribavirin, it has been shown that genetic polymorphisms near the human IL28B gene, encoding interferon lambda 3, are associated with significant differences in response to the treatment.
Peginterferon alfa-2a is a long acting interferon. Interferons are proteins released in the body in response to viral infections . Interferons are important for fighting viruses in the body, for regulating reproduction of cells , and for regulating the immune system.
Ribavirin is the only known treatment for a variety of viral hemorrhagic fevers, including Lassa fever, Crimean-Congo hemorrhagic fever, Venezuelan hemorrhagic fever, and Hantavirus infection, although data regarding these infections are scarce and the drug might be effective only in early stages.
For those with HCV genotype 6, a 48-week treatment protocol of pegylated interferon and ribavirin results in a higher rate of sustained responses than for genotype 1 (86% vs. 52%). Further studies are needed to determine results for shorter 24-week treatments and those given at lower dosages.
Simeprevir, sold under the brand name Olysio among others, is a medication used in combination with other medications for the treatment of hepatitis C. [2] It is specifically used for hepatitis C genotype 1 and 4. [2] Medications it is used with include sofosbuvir or ribavirin and peginterferon-alfa. [2] Cure rates are in 80s to 90s percent.
On November 22, the FDA approved simeprevir for use in combination with peginterferon-alfa and ribavirin. [79] Simeprevir has been approved in Japan for the treatment of chronic hepatitis C infection, genotype 1. [80] There is also current experimental research on non drug related therapies.
The phase-II trial compared three different regimens: four weeks of peginterferon alfa-2b (1.5 micrograms/kg once weekly) plus ribavirin (800 to 1400 mg daily based on patient weight) followed by boceprevir (800 mg three times a day in addition to peginterferon and ribavirin) for 24 weeks or 44 weeks; boceprevir in combination with ...
For the treatment of cases with cirrhosis or liver transplant patients, weight-based ribavirin is sometimes added. Peginterferon with or without sofosbuvir is not recommended in an initial HCV treatment.
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