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Proliferating supporting cells can acquire hair cell fate in mitotic division. The mouse's neonatal supporting cells proliferate after hair cell death and regenerate hair cells after damage. [26] The neonatal cochlea is resistant to hair cell damage caused by exposure to noise or drugs, which are toxic to the cochlea, or auditory nerve, in vivo ...
Damage to hair cells can cause damage to the vestibular system and therefore cause difficulties in balancing. However, other vertebrates, such as the frequently studied zebrafish, and birds have hair cells that can regenerate. [5] [6] The human cochlea contains on the order of 3,500 inner hair cells and 12,000 outer hair cells at birth. [7]
Hair cells are modified neurons, able to generate action potentials which can be transmitted to other nerve cells. These action potential signals travel through the vestibulocochlear nerve to eventually reach the anterior medulla , where they synapse and are initially processed in the cochlear nuclei .
The supporting cells are differentiated from the hair cells, when early embryonic hair cells express ligands that bind to the Notch receptors would prevent them from obtaining the hair cell phenotype, and these cells would differentiate into supporting cells, this is one of the reasons that the supporting cells are able to regenerate new hair ...
Age-related hair cell degeneration is characterized by loss of stereocilia, shrinkage of hair cell soma, and reduction in outer hair cell mechanical properties, suggesting that functional decline in mechanotransduction and cochlear amplification precedes hair cell loss and contributes to age-related hearing loss.
However, others can experience sudden or profound hearing loss and choose a cochlear implant to restore hearing to the affected ear. In this case, a hearing aid would not provide adequate benefit.
Structural damage to hair cells (primarily the outer hair cells) will result in hearing loss that can be characterized by an attenuation and distortion of incoming auditory stimuli. During hair cell death 'scars' develop, which prevent potassium rich fluid of the endolymph from mixing with the fluid on the basal domain. [ 86 ]
Hair Growth Nutraceutical. Dr. Engelman favors this supplement to target hair thinning. “This uses highly concentrated botanicals to address every stage of the growth cycle,” she says, such as ...