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Bone metastasis, or osseous metastatic disease, is a category of cancer metastases that result from primary tumor invasions into bones. Bone-originating primary tumors such as osteosarcoma , chondrosarcoma , and Ewing sarcoma are rare; the most common bone tumor is a metastasis. [ 1 ]
Other bone modifying agents like zoledronic acid and denosumab can reduce prostate cancer bone pain, even though they have little effect on tumor size. [69] Metastases compress the spinal cord in up to 12% of those with metastatic prostate cancer causing pain, weakness, numbness, and paralysis.
Antiandrogens are medications such as flutamide, nilutamide, bicalutamide, enzalutamide, apalutamide, and cyproterone acetate that directly block the actions of testosterone and DHT within prostate cancer cells. In men with metastatic, hormone-sensitive prostate cancer, doctors may recommend adding taxane-based chemotherapy to hormone therapy. [45]
Congolese politician and President of Zaire from 1971 to 1997 (died at the age of 66 from advanced prostate cancer that had metastasized to his bones) [503] [504] Eugene Moore: 1942 – 2016 American politician (died at the age of 73 after his prostate cancer had metastasized to his bones shortly before his death) [505] Earle Morris Jr. 1928 ...
It is well established that human PCa bone metastasis form osteoblastic lesions rather than osteolytic lesions seen in other cancers like breast cancer. [4] [5] Similarly, PC-3 and DU145 cells form osteolytic tumors. To develop an AI-PCa cell model that more closely mimics clinical disease, LNCaP sublines have been generated to provide the most ...
A significant achievement in the commercialization of TAT was the FDA's approval of Xofigo (radium Ra-223 dichloride) in 2013. Xofigo became the first targeted alpha-emitting radiopharmaceutical approved by the FDA, specifically for patients with advanced prostate cancer, particularly those with bone metastases.
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