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Sequenced Treatment Alternatives to Relieve Depression (STAR*D) was a collaborative study on the treatment of depression, funded by the National Institute of Mental Health. Its main focus was on the treatment of depression in patients where the first prescribed antidepressant proved inadequate.
Ketamine has been tested as a rapid-acting antidepressant [13] for treatment-resistant depression in bipolar disorder, and major depressive disorder. [14] Spravato, a nasal spray form of esketamine, was approved by the FDA in 2019 for use in treatment-resistant depression when combined with an oral antidepressant. [15] [16]
The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...
In the immediate aftermath of a high-profile suicide of a beloved celebrity like Naomi Judd, calls to suicide-prevention hotlines tend to increase.
It is now in the process of creating "evidence-based algorithms," that is algorithms created by experts and annotated with the evidence that leads to these algorithms. A schizophrenia algorithm has been created and one on Post Traumatic Stress Disorder was released in July 2005. A general anxiety disorder (GAD) algorithm was released in 2006 ...
Mayberg is known in particular for her work delineating abnormal brain function in patients with major depression using functional neuroimaging. [1] [2] This work led to the first pilot study of deep brain stimulation (DBS), a reversible method of selective modulation of a specific brain circuit, for patients with treatment-resistant depression ...
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