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Aspirin-exacerbated respiratory disease (AERD), also called NSAID-exacerbated respiratory disease (N-ERD) or historically aspirin-induced asthma and Samter's Triad, is a long-term disease defined by three simultaneous symptoms: asthma, chronic rhinosinusitis with nasal polyps, and intolerance of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).
The correlation between the severity of symptoms and measured ibuprofen plasma levels is weak. Toxic effects are unlikely at doses below 100 mg/kg, but can be severe above 400 mg/kg (around 150 tablets of 200 mg units for an average adult male); [47] however, large doses do not indicate the clinical course is likely to be lethal. [48]
Over-the-counter decongestants or antihistamines can help with nasal symptoms, and pain relievers like acetaminophen (Tylenol) or ibuprofen (Advil) can help with muscle aches. RSV Symptoms
Advil is primarily a brand of ibuprofen (a pain reliever in the nonsteroidal anti-inflammatory drug category). [1] Advil has been called a "megabrand" because it offers various "products for a wide range of pain, head cold, and sleep problems."
OTC fever-reducing medication like acetaminophen (Tylenol) or ibuprofen (Advil) “may alleviate aches and pains, and can be helpful for feeling better,” Dr. Schaffner says.
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COX-2 selective inhibitors have fewer gastrointestinal side effects, but promote thrombosis, and some of these agents substantially increase the risk of heart attack. As a result, certain COX-2 selective inhibitors—such as rofecoxib —are no longer used due to the high risk of undiagnosed vascular disease . [ 11 ]
A 2007 Cochrane review assessed the side effects of short-term use of pseudoephedrine at recommended doses as a nasal decongestant. [21] It found that pseudoephedrine had a small risk of insomnia and this was the only side effect that occurred at rates significantly different from placebo. [ 21 ]