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  2. Bicarbonate buffer system - Wikipedia

    en.wikipedia.org/wiki/Bicarbonate_buffer_system

    The pH of tears shift throughout a waking day, rising "about 0.013 pH units/hour" until a prolonged closed-eye period causes the pH to fall again. [15] Most healthy individuals have tear pH in the range of 7.0 to 7.7, where bicarbonate buffering is the most significant, but proteins and other buffering components are also present that are ...

  3. Bicarbonate - Wikipedia

    en.wikipedia.org/wiki/Bicarbonate

    The bicarbonate ion (hydrogencarbonate ion) is an anion with the empirical formula HCO − 3 and a molecular mass of 61.01 daltons; it consists of one central carbon atom surrounded by three oxygen atoms in a trigonal planar arrangement, with a hydrogen atom attached to one of the oxygens.

  4. Acid–base homeostasis - Wikipedia

    en.wikipedia.org/wiki/Acid–base_homeostasis

    This principle is exploited to regulate the pH of the extracellular fluids (rather than just buffering the pH). For the carbonic acid-bicarbonate buffer, a molar ratio of weak acid to weak base of 1:20 produces a pH of 7.4; and vice versa—when the pH of the extracellular fluids is 7.4 then the ratio of carbonic acid to bicarbonate ions in ...

  5. Metabolic acidosis - Wikipedia

    en.wikipedia.org/wiki/Metabolic_acidosis

    Bicarbonate therapy is not recommended for people with less severe acidosis (pH ≥ 7.1), unless severe acute kidney injury is present. In the BICAR-ICU trial, [ 35 ] bicarbonate therapy for maintaining a pH >7.3 had no overall effect on the composite outcome of all-cause mortality and the presence of at least one organ failure at day 7.

  6. Renal compensation - Wikipedia

    en.wikipedia.org/wiki/Renal_compensation

    When the pH of the body falls below 7.35, an acidemia occurs. [2] Similarly, when the pH of the body rises above 7.45, an alkalemia occurs. [2] Renal compensation is one of the many compensatory mechanisms within the body which assist the pH level in ranging between 7.35 and 7.45 as the body cannot function properly when the pH falls out of ...

  7. Buffer solution - Wikipedia

    en.wikipedia.org/wiki/Buffer_solution

    A buffer solution is a solution where the pH does not change significantly on dilution or if an acid or base is added at constant temperature. [1] Its pH changes very little when a small amount of strong acid or base is added to it. Buffer solutions are used as a means of keeping pH at a nearly constant value in a wide variety of chemical ...

  8. Intracellular pH - Wikipedia

    en.wikipedia.org/wiki/Intracellular_pH

    Physiologically normal intracellular pH is most commonly between 7.0 and 7.4, though there is variability between tissues (e.g., mammalian skeletal muscle tends to have a pH i of 6.8–7.1). [4] [5] There is also pH variation across different organelles, which can span from around 4.5 to 8.0. [6] [7] pH i can be measured in a number of ...

  9. Acidosis - Wikipedia

    en.wikipedia.org/wiki/Acidosis

    The rate of cellular metabolic activity affects and, at the same time, is affected by the pH of the body fluids. In mammals, the normal pH of arterial blood lies between 7.35 and 7.50 depending on the species (e.g., healthy human-arterial blood pH varies between 7.35 and 7.45). [citation needed]