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A meta-analysis of such expression profiles was performed to derive novel conclusions and to validate the known findings. [148] Meta-analysis of whole genome sequencing studies provides an attractive solution to the problem of collecting large sample sizes for discovering rare variants associated with complex phenotypes.
The design of a study defines the study type (descriptive, correlational, semi-experimental, experimental, review, meta-analytic) and sub-type (e.g., descriptive-longitudinal case study), research problem, hypotheses, independent and dependent variables, experimental design, and, if applicable, data collection methods and a statistical analysis ...
The aim of the PRISMA statement is to help authors improve the reporting of systematic reviews and meta-analyses. [3] PRISMA has mainly focused on systematic reviews and meta-analysis of randomized trials, but it can also be used as a basis for reporting reviews of other types of research (e.g., diagnostic studies, observational studies).
This measure of effect has greater precision (less uncertainty) than the individual studies, but it may be biased by differences between the studies in study design, the type of evidence, or other key characteristics. [4] In qualitative research, methods of synthesis include narrative synthesis and meta-ethnography. Narrative synthesis allows ...
A meta-analysis is typically a systematic review using statistical methods to effectively combine the data used on all selected studies to produce a more reliable result. [3] Torraco (2016) [4] describes an integrative literature review. The purpose of an integrative literature review is to generate new knowledge on a topic through the process ...
A meta-analysis with some or all studies having more than two arms is called network meta-analysis, indirect meta-analysis, or a multiple treatment comparison. Despite also being an umbrella term, meta-analysis sometimes implies that all included studies have strictly two arms each—same two treatments in all trials—to distinguish itself ...
Examples of such works are scientific reviews and meta-analyses. These and related practices face various challenges and are a subject of metascience. Various issues with included or available studies such as, for example, heterogeneity of methods used may lead to faulty conclusions of the meta-analysis. [115]
A research proposal is a document proposing a research project, generally in the sciences or academia, and generally constitutes a request for sponsorship of that research. [1] Proposals are evaluated on the cost and potential impact of the proposed research, and on the soundness of the proposed plan for carrying it out. [ 2 ]