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Mitochondrial biogenesis is the process by which cells increase mitochondrial numbers. [1] [2] It was first described by John Holloszy in the 1960s, when it was discovered that physical endurance training induced higher mitochondrial content levels, leading to greater glucose uptake by muscles. [3]
A mitochondrion (pl. mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi.Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. [2]
The available oxygen and energy supply, and disturbances of muscle ion homeostasis are the main factors determining exercise performance, at least during brief very intense exercise. Each muscle contraction involves an action potential that activates voltage sensors, and so releases Ca 2+ ions from the muscle fibre 's sarcoplasmic reticulum .
In biology, homeostasis (British also homoeostasis; / h ɒ m i oʊ ˈ s t eɪ s ɪ s,-m i ə-/) is the state of steady internal physical and chemical conditions maintained by living systems. [1] This is the condition of optimal functioning for the organism and includes many variables, such as body temperature and fluid balance , being kept ...
In organelles like the ER and mitochondria, the response is slightly more complex. Both UPR mechanisms are conceptually similar in that they are activated by the accumulation of misfolded/ unfolded proteins and induce the translational upregulation of molecular chaperones and proteases to process proteins and restore homeostasis. [10] Despite ...
Mitochondria are dynamic organelles with the ability to fuse and divide , forming constantly changing tubular networks in most eukaryotic cells. These mitochondrial dynamics, first observed over a hundred years ago [ 1 ] are important for the health of the cell, and defects in dynamics lead to genetic disorders .
PARGC1A gene key to weight loss. At the study’s conclusion, researchers found that participants in the exercise group who had the most “skinny genes” lost up to 5 kg (about 11 lbs) during ...
Mitochondria-associated membranes (MAMs) represent regions of the endoplasmic reticulum (ER) which are reversibly tethered to mitochondria. These membranes are involved in import of certain lipids from the ER to mitochondria and in regulation of calcium homeostasis , mitochondrial function, autophagy and apoptosis .