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The blood–CSF boundary at the choroid plexus is a membrane composed of epithelial cells and tight junctions that link them. [14] There is a CSF-brain barrier at the level of the pia mater, but only in the embryo. [15] Similar to the blood–brain barrier, the blood–CSF barrier functions to prevent the passage of most blood-borne substances ...
In anatomy, the meninges (/ m ə ˈ n ɪ n dʒ iː z /; [1] [2] sg. meninx / ˈ m iː n ɪ ŋ k s, ˈ m ɛ n ɪ ŋ k s /; [3] from Ancient Greek μῆνιγξ (mêninx) 'membrane') [4] are the three membranes that envelop the brain and spinal cord. In mammals, the meninges are the dura mater, the arachnoid mater, and the pia mater.
Once the brain is reached, they break down the blood–brain barrier to enter the Cerebrospinal Fluid (CSF). There the cancerous cells seed and disseminate into the leptomeninges which are composed of the arachnoid and the pia. The CSF continues to carry neoplastic cells through the brain tracts and spreads the cancerous cells. [citation needed]
The cranial pia mater joins with the ependyma, which lines the cerebral ventricles to form choroid plexuses that produce cerebrospinal fluid. Together with the other meningeal layers, the function of the pia mater is to protect the central nervous system by containing the cerebrospinal fluid, which cushions the brain and spine. [7]
Any substance entering the central nervous system from the blood or cerebrospinal fluid (CSF) must cross the glia limitans. The two different classifications of glial limiting membrane, the glia limitans perivascularis and the glia limitans superficialis, have nearly identical structures, however, they can be distinguished from each other by ...
The cerebrospinal fluid (CSF) within the skull and spine provides further protection and also buoyancy, and is found in the subarachnoid space between the pia mater and the arachnoid mater. [citation needed] The CSF that is produced in the ventricular system is also necessary for chemical stability, and the provision of nutrients needed by the ...
The blood–brain barrier becomes more permeable, leading to "vasogenic" cerebral edema (swelling of the brain due to fluid leakage from blood vessels). Large numbers of white blood cells enter the CSF, causing inflammation of the meninges and leading to "interstitial" edema (swelling due to fluid between the cells).
The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood. [1]