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2. CRISPR gene editing - Wikipedia

   en.wikipedia.org/wiki/CRISPR_gene_editing

   CRISPR can be used to suppress mutations which cause gain of function, and also to repair mutations causing loss of function in neurological disorders. [200] The gene editing tool has become a foothold in vivo application for assimilation of molecular pathways. CRISPR is unique to the development of solving neurological diseases for several ...

3. Human germline engineering - Wikipedia

   en.wikipedia.org/wiki/Human_germline_engineering

   According to Pearce, “the question of [human germline engineering] comes down to an analysis of risk-reward ratios – and our basic ethical values, themselves shaped by our evolutionary past.” [69] Bioethicist Julian Savulescu in turn proposes the principle of procreative beneficence, according to which “couples (or single reproducers ...

4. Hypertensive heart disease - Wikipedia

   en.wikipedia.org/wiki/Hypertensive_heart_disease

   In addition, hypertension precedes heart failure in 90% of cases, [7] and the majority of heart failure in the elderly may be attributable to hypertension. [17] Hypertensive heart disease was estimated to be responsible for 1.0 million deaths worldwide in 2004 (or approximately 1.7% of all deaths globally), and was ranked 13th in the leading ...

5. Comparison of international blood pressure guidelines

   en.wikipedia.org/wiki/Comparison_of...

   BP >140/90 and low-risk for CVD: Lifestyle changes BP >140/90 and CVD risk factors or failed lifestyle changes: monotherapy with thiazide-type diuretic, ACEI/ARB, and/or CCB BP >160/100: Two from different classes: thiazide-type diuretic, ACEI/ARB, and/or CCB WHO 2021 [6] General High CVD risk, diabetes or CKD. Previous CVD <140/90 <130 SBP ...

6. CRISPR activation - Wikipedia

   en.wikipedia.org/wiki/CRISPR_activation

   Unlike traditional CRISPR-Cas9, which introduces double-strand breaks to edit genes, CRISPRa employs a modified, catalytically inactive Cas9 (dCas9) fused with transcriptional activators to target promoter or enhancer regions, thereby boosting gene transcription. This method allows for precise control of gene expression, making it a valuable ...

7. Scientists Find This Type of Exercise Cuts Heart Disease Risk ...

   www.aol.com/scientists-type-exercise-cuts-heart...

   Walking is a proven means of reducing many of the major risk factors of heart disease, including blood sugar, blood pressure, cholesterol levels, and a high body mass index, Dr. Sagbir continues.

8. Man accused of attacking Colorado reporter has had mental ...

   www.aol.com/man-accused-attacking-colorado...

   A man accused of attacking a Colorado reporter after questioning whether he was a citizen and saying “This is Trump’s America now” has had mental health issues for years, his lawyer said.

9. Human genetic enhancement - Wikipedia

   en.wikipedia.org/wiki/Human_genetic_enhancement

   CRISPR technology is a promising tool not only for genetic disease corrections but also for the prevention of viral and bacterial infections. Utilizing CRISPR–Cas therapies, researchers have targeted viral infections like HSV-1, EBV, HIV-1, HBV, HPV, and HCV, with ongoing clinical trials for an HIV-clearing strategy named EBT-101 ...