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Guidelines on the choice of agents and how best to step up treatment for various subgroups in hypertension (high blood pressure) have changed over time and differ between countries. A Comparison of International Guidelines on Goal Blood Pressure and Initial Therapy for Adults With Hypertension (adapted from JNC 8 guidelines [ 1 ] )
Researchers are predicting that greater numbers of people will develop high blood pressure, which is a major risk factor for heart attack and stroke. (Getty Images) (Prostock-Studio via Getty Images)
There are more women than men with hypertension, [19] and, although men develop hypertension earlier in life, [20] hypertension in women is less well controlled. [21] [22] The consequences of high blood pressure in women are a major public health problem and hypertension is a more important contributory factor in heart attacks in women than men ...
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease is a peer-reviewed open access scientific journal and an official journal of the American Heart Association. [1] Since 2015, it is also published with John Wiley & Sons .
Hypertension is a monthly peer-reviewed scientific journal [1] that was established in 1979. It is published on behalf of the American Heart Association by Lippincott Williams & Wilkins . The editor-in-chief is Rhian M. Touyz.
Off-target genome editing refers to nonspecific and unintended genetic modifications that can arise through the use of engineered nuclease technologies such as: clustered, regularly interspaced, short palindromic repeats ()-Cas9, transcription activator-like effector nucleases (), meganucleases, and zinc finger nucleases (ZFN). [1]
CRISPR gene editing (CRISPR, pronounced / ˈ k r ɪ s p ə r / (crisper), refers to a clustered regularly interspaced short palindromic repeats") is a genetic engineering technique in molecular biology by which the genomes of living organisms may be modified.
CRISPR interference (CRISPRi) is a genetic perturbation technique that allows for sequence-specific repression of gene expression in prokaryotic and eukaryotic cells. [1] It was first developed by Stanley Qi and colleagues in the laboratories of Wendell Lim , Adam Arkin, Jonathan Weissman , and Jennifer Doudna . [ 2 ]