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In vitro testing demonstrated that AOH1996 inhibited the growth and induced cell cycle arrest and apoptotic cell death in a wide variety of cancer cell lines, but had no effect on several normal, nonmalignant cell types. [6] [7] In mouse and dog animal models, there were no observed side effects or toxicity even at six times the effective dose. [3]
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It is believed to work by blocking a person's immune system from recognizing this antigen. [2] Rh o (D) immune globulin came into medical use in the 1960s, [4] following the pioneering work of John G. Gorman. In 1980, Gorman shared the Lasker-DeBakey Clinical Medical Research Award for pioneering work on the rhesus blood group system. [5]
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Saunders had developed the hospice method through her work with terminally ill patients. Then, as now, it was as much a philosophy as a health service: pain relief and comfort, counseling for patients and families and spiritual guidance, if requested.
But, at the end of the day, they still work — they'll clean your laundry and make it smell good. They weigh less than traditional detergents, take up less storage space, and won't cause a mess ...