Search results
Results From The WOW.Com Content Network
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. [1][2] The function of TFs is to regulate—turn on and off—genes in order to make sure that they are ...
Transcription factors are proteins that bind genomic regulatory sites. Identification of genomic regulatory elements is essential for understanding the dynamics of developmental, physiological and pathological processes. Recent advances in chromatin immunoprecipitation followed by sequencing (ChIP-seq) have provided powerful ways to identify ...
6667 20683 Ensembl ENSG00000185591 ENSMUSG00000001280 UniProt P08047 O89090 RefSeq (mRNA) NM_001251825 NM_003109 NM_138473 NM_013672 RefSeq (protein) NP_001238754 NP_003100 NP_612482 NP_038700 Location (UCSC) Chr 12: 53.38 – 53.42 Mb Chr 15: 102.31 – 102.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor Sp1, also known as specificity protein 1* is a protein ...
DNA binding sites were finally confirmed in both systems [9] [10] [11] with the advent of DNA sequencing techniques. From then on, DNA binding sites for many transcription factors, restriction enzymes and site-specific recombinases have been discovered using a profusion of experimental methods.
TRANSFAC 7.0 Public 2005. TRANSFAC (TRANScription FACtor database) is a manually curated database of eukaryotic transcription factors, their genomic binding sites and DNA binding profiles. The contents of the database can be used to predict potential transcription factor binding sites .
ETS transcription factor family. Structure of Ets-1 DNA binding autoinhibition. [1] In the field of molecular biology, the ETS (E26 transformation-specific[2] or E-twenty-six. (Erythroblast Transformation Specific)[3]) family is one of the largest families of transcription factors and is unique to animals. There are 28 genes in humans [4], 27 ...
Regulatory elements are binding sites for transcription factors, which are involved in gene regulation. [1] Cis-regulatory modules perform a large amount of developmental information processing. [1] Cis-regulatory modules are non-random clusters at their specified target site that contain transcription factor binding sites. [1]
A transcription factor is a protein that binds to specific DNA sequences (enhancer or promoter), either alone or with other proteins in a complex, to control the rate of transcription of genetic information from DNA to messenger RNA by promoting (serving as an activator) or blocking (serving as a repressor) the recruitment of RNA polymerase. [3 ...