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Vitamin B12 deficiency, also known as cobalamin deficiency, is the medical condition in which the blood and tissue have a lower than normal level of vitamin B 12. [ 5 ] Symptoms can vary from none to severe. [ 1 ] Mild deficiency may have few or absent symptoms. [ 1 ]
Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [ 8 ]
Folate deficiency (vitamin B9 deficiency) can cause glossitis, along with macrocytic anemia, thrombocytopenia, leukopenia, diarrhea, fatigue and possibly neurological signs. [7] Apart from pernicious anemia discussed above, any other cause of vitamin B12 deficiency can cause glossitis, which tends to be painful, smooth and shiny. [7]
Pernicious anaemia is a lifelong condition that affects nearly 5 in 100,000 people in the UK.
Endocrinology. Vitamin deficiency is the condition of a long-term lack of a vitamin. When caused by not enough vitamin intake it is classified as a primary deficiency, whereas when due to an underlying disorder such as malabsorption it is called a secondary deficiency. An underlying disorder can have 2 main causes:
Several factors can cause a person to have classic signs of dementia, including a deficiency in vitamin B12. “Vitamin B12 deficiency can cause cognitive impairment, including impairments in ...
[6] [14] [25] Vitamin B 12 deficiency can also cause symptoms of mania and psychosis. [26] [27] Among other problems, weakened immunity, reduced fertility and interruption of blood circulation in women may occur. [28] The main type of vitamin B12 deficiency anemia is pernicious anemia, [29] characterized by a triad of symptoms:
Atrophic gastritis is a process of chronic inflammation of the gastric mucosa of the stomach, leading to a loss of gastric glandular cells and their eventual replacement by intestinal and fibrous tissues. As a result, the stomach's secretion of essential substances such as hydrochloric acid, pepsin, and intrinsic factor is impaired, leading to ...