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In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
QFD house of quality for enterprise product development processes. The term systems engineering can be traced back to Bell Telephone Laboratories in the 1940s. [1] The need to identify and manipulate the properties of a system as a whole, which in complex engineering projects may greatly differ from the sum of the parts' properties, motivated various industries, especially those developing ...
The system is based on LD50 determination in rats, thus an oral solid agent with an LD50 at 5 mg or less/kg bodyweight is Class Ia, at 5–50 mg/kg is Class Ib, LD50 at 50–2000 mg/kg is Class II, and at LD50 at the concentration more than 2000 mg/kg is classified as Class III. Values may differ for liquid oral agents and dermal agents. [1]
Subpart 37.2 defines advisory and assistance services and provides that the use of such services is a legitimate way to improve the prospects for program or systems success. FAR Part 37.201(c) defines engineering and technical services used in support of a program office during the acquisition cycle.
Instructional design (ID), also known as instructional systems design and originally known as instructional systems development (ISD), is the practice of systematically designing, developing and delivering instructional materials and experiences, both digital and physical, in a consistent and reliable fashion toward an efficient, effective, appealing, engaging and inspiring acquisition of ...
Systems engineering is a field focused on the design, integration, and management of complex systems over their life cycles. It is commonly applied in industries like aerospace, defense, and transportation. Systems engineering may also refer to:
ADDIE is an instructional systems design (ISD) framework that many instructional designers and training developers use to develop courses. [1] The name is an acronym for the five phases it defines for building training and performance support tools:
The ISO/IEC 15288 Systems and software engineering — System life cycle processes is a technical standard in systems engineering which covers processes and lifecycle stages, developed by the International Organization for Standardization (ISO) and the International Electrotechnical Commission (IEC).