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In March, researchers announced the successful use of gene therapy to treat two adult patients for X-linked chronic granulomatous disease, a disease which affects myeloid cells and damages the immune system. The study is the first to show that gene therapy can treat the myeloid system. [182]
The journal's first issue was published in 2001, making Current Gene Therapy one of the oldest peer-reviewed journals with a specific focus on Gene Therapy. The original issue focused on viral vectors for gene delivery vectors and use of gene therapy treatments for oncology.
The gene must then be isolated and incorporated, along with other genetic elements, into a suitable vector. This vector is then used to insert the gene into the host genome, creating a transgenic or edited organism. The ability to genetically engineer organisms is built on years of research and discovery on gene function and manipulation.
Gene delivery is a necessary step in gene therapy for the introduction or silencing of a gene to promote a therapeutic outcome in patients and also has applications in the genetic modification of crops. There are many different methods of gene delivery for various types of cells and tissues.
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How vectors work to transfer genetic material. Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).
Mitochondrial transcription factor A is used because it unwinds the mtDNA that enters the mitochondria, which is critical for mtDNA replication. This process can lead to an increase in the amount of mtDNA present in the mitochondria of the target cells. [3] The transduction system has been tweaked and modified, since the first use of protofection.
"Gene Therapy Arrives". Scientific American This page was last edited on 10 November 2024, at 06:28 (UTC). Text is available under the Creative Commons Attribution ...