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It is also used to increase urine pH (alkalinize urine) - this prevents uric acid stones and cystine stones (which form in cystinuria). [2] It is different from citric acid which is citrate bonded by hydrogen ions (or protons) making it acidic. [3] Citric acid does not alkalinize urine as alkali citrate does. [4]
Uricosurics are often used in the treatment of gout, a disease in which uric acid crystals form deposits in the joints. By decreasing plasma uric acid levels, help dissolve these crystals, while limiting the formation of new ones. However, the increased uric acid levels in urine can contribute to kidney stones.
Saturation levels of uric acid in blood may result in one form of kidney stones when the urate crystallizes in the kidney. These uric acid stones are radiolucent, so do not appear on an abdominal plain X-ray. [57] Uric acid crystals can also promote the formation of calcium oxalate stones, acting as "seed crystals". [58]
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In the Middle East, uric acid stones are more common than calcium-containing stones. [25] The number of deaths due to kidney stones is estimated at 19,000 per year being fairly consistent between 1990 and 2010. [121] In North America and Europe, the annual number of new cases per year of kidney stones is roughly 0.5%.
Hyperuricosuria is a medical term referring to the presence of excessive amounts of uric acid in the urine. For men this is at a rate greater than 800 mg/day, and for women, 750 mg/day. [1] Notable direct causes of hyperuricosuria are dissolution of uric acid crystals in the kidneys or urinary bladder, and hyperuricemia.