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The PDQ NCI Cancer Terms Database is a resource of cancer-related terms, curated by a multidisciplinary panel of reviewers, that is released monthly. The NCI Drug Dictionary is a structured list of technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer.
NCI Dictionaries: NCI Dictionary of Cancer Terms (utilizing non-technical language) • NCI Dictionary of Genetics Terms (for healthcare professionals) • NCI Drug Dictionary (includes links for potential clinical trials) NCI in A Short History of the National Institutes of Health, an online exhibit by the Office of NIH History
Cyclophosphamide is a pregnancy category D drug and causes birth defects. First trimester exposure to cyclophosphamide for the treatment of cancer or lupus displays a pattern of anomalies labeled "cyclophosphamide embryopathy", including growth restriction , ear and facial abnormalities, absence of digits and hypoplastic limbs .
According to the NCI Drug Dictionary, "tazemetostat is an orally available, small molecule selective and S-adenosyl methionine (SAM) competitive inhibitor of histone methyl transferase EZH2, with potential antineoplastic activity. Upon oral administration, tazemetostat selectively inhibits the activity of both wild-type and mutated forms of EZH2.
NCI Drug Dictionary. National Cancer Institute. "Tucatinib". NCI Dictionary of Cancer Terms. National Cancer Institute. Clinical trial number NCT02614794 for "A Study of Tucatinib vs. Placebo in Combination With Capecitabine & Trastuzumab in Patients With Advanced HER2+ Breast Cancer (HER2CLIMB)" at ClinicalTrials.gov
NCI Drug Dictionary. "Tarlatamab (Code C175858)". NCI Thesaurus. Clinical trial number NCT05060016 for "A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC) (DeLLphi-301)" at ClinicalTrials.gov
NCI Drug Dictionary. National Cancer Institute. National Cancer Institute. Clinical trial number NCT00878709 for "Study Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer (ExteNET)" at ClinicalTrials.gov
NCI Drug Dictionary. National Cancer Institute. "Capmatinib hydrochloride". National Cancer Institute. Clinical trial number NCT02414139 for "Clinical Study of Oral cMET Inhibitor INC280 in Adult Patients With EGFR Wild-type Advanced Non-small Cell Lung Cancer" at ClinicalTrials.gov