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Scleroderma is also associated with an increased risk of cardiovascular disease. [46] According to a study of an Australian cohort, between 1985 and 2015, the average life expectancy of a person with scleroderma increased from 66 years to 74 years (the average Australian life expectancy increased from 76 to 82 years in the same period). [47]
Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse ...
Primary organ/body part affected Autoantibodies Acceptance as an autoimmune disease Prevalence rate (US) Cit. Alopecia areata: Hair follicles: None specific Confirmed 2.1% [1] [2] Autoimmune angioedema: Skin: C1 inhibitor: Probable Less than 5,000 [3] Autoimmune progesterone dermatitis: Skin Progesterone: Probable Extremely rare [4] Autoimmune ...
Linear scleroderma is a type of localised scleroderma [11] which is an autoimmune disease characterized by a line of thickened skin which can affect the bones and muscles underneath it. It most often occurs in the arms, legs, or forehead, and may occur in more than one area. It is also most likely to be on just one side of the body.
In UPD, a person receives two copies of a chromosome, or part of a chromosome, from one parent and no copies from the other parent due to errors in meiosis I or meiosis II. This acquired homozygosity could lead to development of cancer if the individual inherited a non-functional allele of a tumor suppressor gene.
Sclerodactyly is often preceded by months or even years by Raynaud's phenomenon when it is part of systemic scleroderma. [citation needed] The term "sclerodactyly" comes from Greek skleros 'hard' and daktylos 'digit'. It is generally associated with systemic scleroderma and mixed connective tissue disease, and auto-immune disorders.
One genetic variant associated with Alzheimer’s disease progression is presenilin 2 ... there would be no expectation tau in the other parts of the brain would cause symptoms if this patient had ...
People with scleromyositis have symptoms of both systemic scleroderma and either polymyositis or dermatomyositis, and is therefore considered an overlap syndrome. Although it is a rare disease, it is one of the more common overlap syndromes seen in scleroderma patients, together with MCTD and Antisynthetase syndrome.