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Neuromuscular drugs are chemical agents that are used to alter the transmission of nerve impulses to muscles, causing effects such as temporary paralysis of targeted skeletal muscles. Most neuromuscular drugs are available as quaternary ammonium compounds which are derived from acetylcholine (ACh). [ 1 ]
Since these drugs may cause paralysis of the diaphragm, mechanical ventilation should be at hand to provide respiration. In addition, these drugs may exhibit cardiovascular effects, since they are not fully selective for the nicotinic receptor and hence may have effects on muscarinic receptors . [ 11 ]
Incapacitating agent is a chemical or biological agent which renders a person unable to harm themselves or others, regardless of consciousness. [1]Lethal agents are primarily intended to kill, but incapacitating agents can also kill if administered in a potent enough dose, or in certain scenarios.
Drugs that interfere with nerve function, such as curare, can also cause paralysis. Pseudoparalysis (pseudo-meaning "false, not genuine", from Greek ψεῦδος [7]) is voluntary restriction or inhibition of motion because of pain, incoordination, orgasm, or other cause, and is not due to actual muscular paralysis. [8]
They are often used during surgical procedures and in intensive care and emergency medicine to cause temporary paralysis. Spasmolytics, also known as "centrally acting" muscle relaxant, are used to alleviate musculoskeletal pain and spasms and to reduce spasticity in a variety of neurological conditions.
Researchers found that several popular weight-loss drugs could cause rare but serious complications.
Medications for gastroparesis aim to manage symptoms and may include what are called prokinetic agents. These work by inducing stomach contractions to move food through your digestive tract.
These poisons cause weakness of the skeletal muscles and, when administered in a sufficient dose, eventual death by asphyxiation due to paralysis of the diaphragm. In medicine, curare has been used as a treatment for tetanus and strychnine poisoning and as a paralyzing agent for surgical procedures.