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  2. Selective serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Selective_serotonin...

    Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the ...

  3. Serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Serotonin_reuptake_inhibitor

    Serotonin. A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT). This in turn leads to increased extracellular concentrations of serotonin and, therefore, an increase in serotonergic ...

  4. Biology of depression - Wikipedia

    en.wikipedia.org/wiki/Biology_of_depression

    First, serotonin system dysfunction cannot be the sole cause of depression, because not all patients treated with antidepressants show improvement, despite the fact that most patients still show a rapid increase in synaptic serotonin. Second, if significant mood improvements do occur, this is often not for at least two to four weeks.

  5. Serotonin - Wikipedia

    en.wikipedia.org/wiki/Serotonin

    Serotonin (/ ˌ s ɛr ə ˈ t oʊ n ɪ n, ˌ s ɪər ə-/) [6] [7] [8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.

  6. Mood disorder - Wikipedia

    en.wikipedia.org/wiki/Mood_disorder

    In some cases, more than one mood disorder can be present in an individual, like bipolar disorder and depressive disorder. [citation needed] Mood disorders may also be substance induced, or occur in response to a medical condition. English psychiatrist Henry Maudsley proposed an overarching category of affective disorder. [5]

  7. Major depressive episode - Wikipedia

    en.wikipedia.org/wiki/Major_depressive_episode

    Children with generalized social anxiety disorder may be more likely to experience a major depressive episode. [19] Other risk factors for a depressive episode include: [3] Early childhood trauma; Family history of a mood disorder; Lack of interpersonal relationships; Personality (insecure, worried, stress-sensitive, obsessive, unassertive ...

  8. Pharmacology of antidepressants - Wikipedia

    en.wikipedia.org/wiki/Pharmacology_of...

    While MAOIs, TCAs and SSRIs increase serotonin levels, others prevent serotonin from binding to 5-HT 2A receptors, suggesting it is too simplistic to say serotonin is a "happy neurotransmitter". In fact, when the former antidepressants build up in the bloodstream and the serotonin level is increased, it is common for the patient to feel worse ...

  9. Serotonin pathway - Wikipedia

    en.wikipedia.org/wiki/Serotonin_pathway

    A serotonin pathway identifies aggregate projections from neurons which synthesize and communicate the monoamine neurotransmitter serotonin. [ citation needed ] These pathways are relevant to different psychiatric and neurological disorders.