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Intrinsic factor (IF), cobalamin binding intrinsic factor, [5] also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells (in humans) or chief cells (in rodents) of the stomach. It is necessary for the absorption of vitamin B 12 later on in the distal ileum of the small intestine. [6]
Intrinsic factor is required for the absorption of vitamin B 12 in the diet. A long-term deficiency in vitamin B 12 can lead to megaloblastic anemia, characterized by large fragile red blood cells. Pernicious anaemia results from autoimmune destruction of gastric parietal cells, precluding the synthesis of intrinsic factor and, by extension ...
The same cells in the stomach that produce gastric hydrochloric acid, the parietal cells, also produce a molecule called the intrinsic factor (IF), which binds the B 12 after its release from haptocorrin by digestion, and without which only 1% of vitamin B 12 is absorbed. Intrinsic factor (IF) is a glycoprotein, with a molecular weight of 45 kDa.
The visual system is the physiological basis of visual perception (the ability to detect and process light).The system detects, transduces and interprets information concerning light within the visible range to construct an image and build a mental model of the surrounding environment.
The frontal eye fields (FEF) are a region located in the frontal cortex, more specifically in Brodmann area 8 or BA8, [1] of the primate brain. In humans, it can be more accurately said to lie in a region around the intersection of the middle frontal gyrus with the precentral gyrus , consisting of a frontal and parietal portion. [ 2 ]
Intrinsic factor, a glycoprotein produced by the parietal cells of the stomach, which is necessary for the absorption of vitamin B 12 Topics referred to by the same term This disambiguation page lists articles associated with the title Castle factors .
In turn, much of the output of the posterior parietal cortex goes to areas of frontal motor cortex: the dorsolateral prefrontal cortex, various areas of the secondary motor cortex, and the frontal eye field. The posterior parietal cortex is divided by the intraparietal sulcus to form the dorsal superior parietal lobule and the ventral inferior ...
The intraparietal sulcus (IPS) is located on the lateral surface of the parietal lobe, and consists of an oblique and a horizontal portion.The IPS contains a series of functionally distinct subregions that have been intensively investigated using both single cell neurophysiology in primates [1] [2] and human functional neuroimaging. [3]