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Laropiprant is a prostaglandin D2 binding drug shown to reduce niacin-induced vasodilation and flushing side effects. [ 28 ] [ 72 ] [ 73 ] A clinical trial showed no additional efficacy of Tredaptive in lowering cholesterol when used together with other statin drugs, but did show an increase in other side effects. [ 74 ]
While nicotinic acid (niacin) may be used for this purpose, nicotinamide has the benefit of not causing skin flushing. [4] As a cream, it is used to treat acne, and has been observed in clinical studies to improve the appearance of aging skin by reducing hyperpigmentation and redness. [5] [6] It is a water-soluble vitamin. Side effects are minimal.
Example of a label showing the amount of niacin (Vitamin B3), and specifying to be niacinamide in the ingredient section.. As flour fortification started adding niacin in the US, the United States Government adopted the terms niacin (a shortened form of "nicotinic acid vitamin") and niacinamide in 1942 as alternate names for nicotinic acid and nicotinamide, respectively, and encouraged their ...
It was a combination of the lipid-modifying drug/vitamin niacin in extended release form and the statin drug lovastatin (trade name Mevacor). [1] The combination preparation was developed by Kos Pharmaceuticals, Inc., which was acquired by Abbott Laboratories in 2006, subsequently transferred to AbbVie Inc. when that company was spun off from ...
Laropiprant was a drug used in combination with nicotinic acid to reduce blood cholesterol (LDL and VLDL) that is no longer sold, due to increases in side-effects with no cardiovascular benefit. Laropiprant itself has no cholesterol lowering effect, but it reduces facial flushes induced by nicotinic acid.
Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B 3). [2] Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. [1] Areas of the skin exposed to friction and radiation are typically affected first. [1] Over time affected skin may become darker, stiffen, peel, or bleed. [1] [3]
Inositol nicotinate is generally safe when taken by mouth, but possible side effects include: Stomach upset; Intestinal gas; Nausea; Liver damage (similar to other niacin products) [1] It is marketed as "no-flush" niacin, but research suggests that the lack of flushing may be due to its limited conversion to active niacin. [4]
Dianazene was the name given by L. Ron Hubbard to a vitamin compound containing iron, vitamin C, and various B vitamins, including especially large doses of niacin.. Hubbard promoted it as a form of protection against radiation poisoning during the 1950s, saying that "Dianazene runs out radiation — or what appears to be radiation.