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  2. RNA therapeutics - Wikipedia

    en.wikipedia.org/wiki/RNA_Therapeutics

    The main types of RNA therapeutics are those based on messenger RNA (mRNA), antisense RNA (asRNA), RNA interference (RNAi), and RNA aptamers. Of the four types, mRNA-based therapy is the only type which is based on triggering synthesis of proteins within cells, making it particularly useful in vaccine development. [3]

  3. MRNA-based disease diagnosis - Wikipedia

    en.wikipedia.org/wiki/MRNA-based_disease_diagnosis

    RNA sequencing (RNA-seq) RNA-seq is a high-throughput RNA sequencing technology that allows scientists to profile the entire RNA (transcriptome). Therefore, novel transcripts and gene expression level can be identified based on cDNA libraries. This method can be used for cancer diagnosis and treatment evaluation. [13]

  4. mRNA vaccine - Wikipedia

    en.wikipedia.org/wiki/MRNA_vaccine

    An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. [1] The vaccine delivers molecules of antigen -encoding mRNA into cells , which use the designed mRNA as a blueprint to build foreign protein that would normally be produced by a pathogen (such as a virus ) or by a ...

  5. List of gene therapies - Wikipedia

    en.wikipedia.org/wiki/List_of_gene_therapies

    Exagamglogene autotemcel (Casgevy): treatment for sickle cell disease. [11] Gendicine: treatment for head and neck squamous cell carcinoma; Idecabtagene vicleucel (Abecma): treatment for multiple myeloma [12] Lovotibeglogene autotemcel (Lyfgenia): treatment for sickle cell disease. [11] Nadofaragene firadenovec (Adstiladrin): treatment for ...

  6. Messenger RNA - Wikipedia

    en.wikipedia.org/wiki/Messenger_RNA

    A 5' cap (also termed an RNA cap, an RNA 7-methylguanosine cap, or an RNA m 7 G cap) is a modified guanine nucleotide that has been added to the "front" or 5' end of a eukaryotic messenger RNA shortly after the start of transcription. The 5' cap consists of a terminal 7-methylguanosine residue that is linked through a 5'-5'-triphosphate bond to ...

  7. Gene therapy - Wikipedia

    en.wikipedia.org/wiki/Gene_therapy

    Gene therapy approaches to replace a faulty gene with a healthy gene have been proposed and are being studied for treating some genetic diseases. As of 2017, 11.1% of gene therapy clinical trials targeted monogenic diseases. [74]: 9

  8. Antisense therapy - Wikipedia

    en.wikipedia.org/wiki/Antisense_therapy

    Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content modulation through splicing site binding on pre-mRNA. [1]

  9. List of RNAs - Wikipedia

    en.wikipedia.org/wiki/List_of_RNAs

    5' small nucleolar RNA capped and 3' polyadenylated long noncoding RNA - SRP RNA: signal recognition particle RNA CL00003: ssRNA single stranded RNA - stRNA: small temporal RNA - tasiRNA: trans-acting siRNA - tmRNA: transfer-messenger RNA RF00023: Bacterial RNA molecule with dual tRNA-like and messenger RNA-like properties uRNA U spliceosomal ...

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