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Sorafenib is a protein kinase inhibitor with activity against many protein kinases, including VEGFR, PDGFR and RAF kinases. [4] [5] Of the RAF kinases, sorafenib is more selective for c-Raf than B-RAF. [6] (See BRAF (gene)#Sorafenib for details the drug's interaction with B-Raf.) Sorafenib treatment induces autophagy, [7] which
Trimethoprim serves as a competitive inhibitor of dihydrofolate reductase (DHFR), hence inhibiting the de novo synthesis of tetrahydrofolate, the biologically active form of folate. [ 14 ] Tetrahydrofolate is crucial in the synthesis of purines , thymidine , and methionine which are needed for the production of DNA and proteins [ 28 ] during ...
Pseudoephedrine is widely available over-the-counter (OTC) in both single-drug and combination preparations. [30] [22] [13] [2] Availability of pseudoephedrine has been restricted starting in 2005 as it can be used to synthesize methamphetamine. [13] [2] Phenylephrine has replaced pseudoephedrine in many over-the-counter oral decongestant ...
After an FDA advisory committee said the decongestant phenylephrine, an ingredient found in many oral cold and flu medications, is ineffective, experts weigh in on alternatives.
Thymidine analogue inhibitor Efavirenz: HIV Mylan: NNRTI 1998 Elvitegravir: HIV Gilead Sciences Integrase inhibitor 2012 (Fixed-dose combo Stribild) 2014 (single pill) 2015 ; Emtricitabine: HIV Gilead Sciences NRTI 2003 Enfuvirtide: HIV Entry inhibitor 2003 Ensitrelvir: COVID-19: Shionogi: 3C-like protease inhibitor Entecavir: HIV NRTI 2005
These drugs are among the most widely sold drugs in the world, and are generally considered effective. [3] When these medications are used long term, the lowest effective dose should be taken. [4] They may also be taken only when symptoms occur in those with frequent problems. [5] Proton-pump inhibitors are named using the suffix "-prazole".
A new opioid-free pain medication was approved by the U.S. Food and Drug Administration (FDA) on Thursday, marking a non-addictive alternative for patients. Journavx (suzetrigine), made by Vertex ...
Lastly, over-the-counter alternatives might offer benefits when taken with prescription antidepressants. A handful of the most popular ones include: St. John’s wort