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The arginine catabolic mobile element (ACME) is a mobile genetic element of Staphylococcus bacterial species. This genetic element provides for several immune modulating functions, including resistance to polyamines which serve as a non-specific immune response both on intact skin and following the inflammatory response in wound healing.
People who are hospitalized, including the elderly, are often immunocompromised and susceptible to infection of all kinds, including MRSA; an infection by MRSA is called healthcare-associated or hospital-acquired methicillin-resistant S. aureus (HA-MRSA). [1] [5] [22] [23] Generally, those infected by MRSA stay infected for just under 10 days ...
Methicillin was developed by Beecham in 1959. [4] It was previously used to treat infections caused by susceptible gram-positive bacteria, in particular, penicillinase -producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins.
SCCmec is a 21 to 60 kb long genetic element that confers broad-spectrum β-lactam resistance to MRSA. [2] Moreover, additional genetic elements like Tn 554 , pT181, and pUB110 can be found in SCC mec, which have the capability to render resistance to various non-β-lactam drugs.
MRSA ST398 is a clonal complex 398 (CC398). This means that the strain had emerged in a human clinic, without any obvious or understandable causes. MRSA ST398, a specific strain of MRSA, is commonly found in livestock, and can cause infections in humans who come into contact with infected animals. [1]
Ceftaroline fosamil / s ɛ f ˈ t ær oʊ l iː n /, brand name Teflaro in the US and Zinforo in Europe, [1] [2] is a cephalosporin antibiotic with anti-MRSA activity. [3] Ceftaroline fosamil is a prodrug of ceftaroline. It is active against methicillin-resistant Staphylococcus aureus (MRSA) and other Gram-positive bacteria.
It is a colorless solid. A related isomer is 1,2,3,4-tetrachloro-5-nitrobenzene. It is used as a standard for quantitative analysis by nuclear magnetic resonance. [4] [5] 1,2,4,5-Tetrachloro-3-nitrobenzene is also a fungicide used to prevent dry rot and sprouting on potatoes during storage. [6] [7]
Statement is quite controversial. Many centres still use Vancomycin as first line, due to the safety profile and cost of Linezolid. Also mentionable that linezolid is bacteriostat