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Testosterone is in the androgen family of medications. [9] Testosterone was first isolated in 1935, and approved for medical use in 1939. [12] [13] Rates of use have increased three times in the United States between 2001 and 2011. [14] It is on the World Health Organization's List of Essential Medicines. [15] It is available as a generic ...
4-Androstene-3,6,17-trione (4-AT; also marketed as 6-OXO or 4-etioallocholen-3,6,17-trione) is a drug or nutritional supplement that may increase the testosterone-estrogen ratio, but has no proven effect on body composition. Its use can be detected in urine.
Testosterone is the primary male sex hormone and androgen in males. [3] In humans, testosterone plays a key role in the development of male reproductive tissues such as testicles and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.
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Testosterone replacement therapies have been shown to improve blood glucose management. [13] [14] Still, "it is prudent not to start testosterone therapy in men with diabetes solely for the purpose of improving metabolic control if they show no signs and symptoms of hypogonadism." [15]
Stimulation of lean body mass and prevention of bone loss in elderly men, as some studies indicate. [14] [15] [16] However, a 2006 placebo-controlled trial of low-dose testosterone supplementation in elderly men with low levels of testosterone found no benefit on body composition, physical performance, insulin sensitivity, or quality of life. [17]
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