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They are given by injection. [2] Common side effects may include joint pain, rash, vomiting, and headache. [4] Serious side effects may include heart attacks, stroke, increased cancer growth, or pure red cell aplasia. [2] It is unclear if use is safe during pregnancy. [5] [6] They work similar to naturally occurring erythropoietin. [1]
Patients are typically given one or two 100,000 I.U. vials of ulinastatin (reconstituted in 100 ml of dextrose 5% or 100 ml of 0.9% normal saline) by intravenous infusion over the course of one hour, one to three times per day for three to five days. The dosage may be adjusted according to patients' age and the severity of symptoms.
Rank Drug Trade name Type Main indications Company Sales (USD millions/year) ∆ vs 2014 1 Adalimumab: Humira Biologic Rheumatoid arthritis: AbbVie Inc. 14,012 1,469
The average cost per patient in the US was US$8,447 in 2009. [31] Epoetin alfa has accounted for the single greatest drug expenditure paid by the US Medicare system; in 2010, the program paid US$2 billion for the medication. [32] [33]
Cost per procedure, sometimes known as price per procedure, is a medical pricing model which describes the average cost of receiving a certain medical procedure. [1]
Methoxy polyethylene glycol-epoetin beta, sold under the brand name Mircera, is a long-acting erythropoietin receptor activator (CERA) used for the treatment of anaemia associated with chronic kidney disease. [4]
The FDA subsequently announced that compounding pharmacies could continue to sell hydroxyprogesterone caproate at their usual cost of approximately US$10 to US$20 per dose without fear of enforcement action by the agency. [27] [148] KV Pharmaceutical also opted to reduced its price of Makena to US$690 per dose.
The authors calculated that an annual cost of $4,500 would meet an acceptable $100,000 per QALY standard. [24] On 26 October 2018, the maker of the drug, Amgen , announced a 60% cut in price and the drug at that date cost $5,850 per year.
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