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Alpha-adrenergic agonists are a class of sympathomimetic agents that selectively stimulates alpha adrenergic receptors. The alpha-adrenergic receptor has two subclasses α 1 and α 2. Alpha 2 receptors are associated with sympatholytic properties. Alpha-adrenergic agonists have the opposite function of alpha blockers.
The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like beta blockers, beta-2 (β 2) antagonists and alpha-2 (α 2) agonists, which are used to treat high ...
An adrenergic agonist is a drug that stimulates a response from the adrenergic receptors. The five main categories of adrenergic receptors are: α 1 , α 2 , β 1 , β 2 , and β 3 , although there are more subtypes, and agonists vary in specificity between these receptors, and may be classified respectively.
The alpha-2 (α 2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the G i heterotrimeric G-protein. It consists of three highly homologous subtypes, including α 2A - , α 2B - , and α 2C -adrenergic .
alpha-1 (α 1) adrenergic receptors are G protein-coupled receptors (GPCRs) associated with the G q heterotrimeric G protein. α 1-adrenergic receptors are subdivided into three highly homologous subtypes, i.e., α 1A-, α 1B-, and α 1D-adrenergic receptor subtypes.
150 11551 Ensembl ENSG00000150594 ENSMUSG00000033717 UniProt P08913 Q01338 RefSeq (mRNA) NM_000681 NM_007417 RefSeq (protein) NP_000672 NP_031443 Location (UCSC) Chr 10: 111.08 – 111.08 Mb Chr 19: 54.03 – 54.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The alpha-2A adrenergic receptor (α 2A adrenoceptor), also known as ADRA2A, is an α 2 -adrenergic receptor, and also ...
They are mainly used in research, having found limited clinical application in human medicine. They are extensively used in veterinary medicine to reverse the effects of alpha-2 agonist drugs used as sedatives, like xylazine, medetomidine and dexmedetomidine. Alpha-2 blockers increase noradrenaline release.
There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins. Different subtypes show different patterns of activation. The majority of alpha-1 receptors are directed toward the function of epinephrine, a hormone that has to do with the fight-or-flight response.