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The French Louis Pasteur (1822–1895) and German Robert Koch (1843–1910) are the two greatest figures in medical microbiology and in establishing acceptance of the germ theory of disease (germ theory). [1] In 1882, fueled by national rivalry and a language barrier, the tension between Pasteur and the younger Koch erupted into an acute ...
Koch's postulates (/ k ɒ x / KOKH) [2] are four criteria designed to establish a causal relationship between a microbe and a disease. The postulates were formulated by Robert Koch and Friedrich Loeffler in 1884, based on earlier concepts described by Jakob Henle , and the statements were refined and published by Koch in 1890. [ 3 ]
Heinrich Hermann Robert Koch (/ k ɒ x / KOKH; [1] [2] German: [ˈʁoːbɛʁt ˈkɔx] ⓘ; 11 December 1843 – 27 May 1910) was a German physician and microbiologist.As the discoverer of the specific causative agents of deadly infectious diseases including tuberculosis, cholera and anthrax, he is regarded as one of the main founders of modern bacteriology.
Pasteur was then asked by Napoleon III to study French wineries because a large portion of French wine was contaminated. [45] Pasteur believed that heating the wine could destroy the microorganisms which had contaminated it. This process became known as pasteurization. [49] [50] Louis Pasteur's experiment to disprove spontaneous generation
1876 – Demonstration that microbes can cause disease-anthrax (Robert Koch) 1877 – Mast cells (Paul Ehrlich) 1878 – Confirmation and popularization of the germ theory of disease (Louis Pasteur) 1880 – 81 Theory that bacterial virulence could be attenuated by culture in vitro and used as vaccines.
Pasteur created several vaccines over the course of his lifetime. His work prior to rabies involved attenuation of pathogens, but not through serial passage. In particular, Pasteur worked with cholera and found that if he cultured bacteria for long periods of time, he could create an effective vaccine.
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Louis Pasteur and Robert Koch were contemporaries of Cohn, and are often considered to be the fathers of modern microbiology [16] and medical microbiology, respectively. [18] Pasteur is most famous for his series of experiments designed to disprove the then widely held theory of spontaneous generation , thereby solidifying microbiology's ...