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An axo-axonic synapse is a type of synapse, formed by one neuron projecting its axon terminals onto another neuron's axon. [ 1 ] Axo-axonic synapses have been found and described more recently than the other more familiar types of synapses, such as axo-dendritic synapses and axo-somatic synapses.
The synapse is the primary unit of information transfer in the nervous system, and correct synaptic contact creation during development is essential for normal brain function. Genetic mutations can disrupt synapse formation and function, contributing to the development of neurodevelopmental and neurodegenerative disorders. [ 46 ]
Comment: The featured synapse is shown on the cell body - which strikes me as very unusual. Debivort 05:56, 13 July 2007 (UTC) [ reply ] Probably from the angle the image is drawn, which is why the synapse is magnified to show that there is a very tiny gap between the synapse and cell.
The strength of a synapse has been defined by Bernard Katz as the product of (presynaptic) release probability pr, quantal size q (the postsynaptic response to the release of a single neurotransmitter vesicle, a 'quantum'), and n, the number of release sites. "Unitary connection" usually refers to an unknown number of individual synapses ...
Presynaptic inhibition is a phenomenon in which an inhibitory neuron provides synaptic input to the axon of another neuron (axo-axonal synapse) to make it less likely to fire an action potential. Presynaptic inhibition occurs when an inhibitory neurotransmitter, like GABA, acts on GABA receptors on the axon terminal.
A model view of the synapse. Synaptic pruning, a phase in the development of the nervous system, is the process of synapse elimination that occurs between early childhood and the onset of puberty in many mammals, including humans. [1] Pruning starts near the time of birth and continues into the late-20s. [2]
A neural connection is formed when an axosomatic synapse is created Adult expression. In a study done in rat spinal cords, increased netrin-1, UNC-5 homologue levels were observed compared to lower levels measured in the embryo. [10] From this study multiple mRNA transcripts were detected by northern blot analysis.
An axo-axonal gated synapse: Neuron C gates the synapse between Neuron A and B. Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity .