Search results
Results From The WOW.Com Content Network
It is desirous for the value of LD 50 to be as large as possible, to decrease risk of lethal effects and increase the therapeutic window. In the above formula, TI safety increases as the difference between LD 50 and ED 50 increases—hence, a higher safety-based therapeutic index indicates a larger therapeutic window, and vice versa.
The near-infrared (NIR) window (also known as optical window or therapeutic window) defines the range of wavelengths from 650 to 1350 nanometre (nm) where light has its maximum depth of penetration in tissue. [1] Within the NIR window, scattering is the most dominant light-tissue interaction, and therefore the propagating light becomes diffused ...
The therapeutic window is the amount of a medication between the amount that gives an effect (effective dose) and the amount that gives more adverse effects than desired effects. For instance, medication with a small pharmaceutical window must be administered with care and control, e.g. by frequently measuring blood concentration of the drug ...
The line between efficacy and toxicity is dependent upon the particular patient, although the dose administered by a physician should fall into the predetermined therapeutic window of the drug. The importance of determining the therapeutic range of a drug cannot be overstated.
Pharmacology is the science of drugs and medications, [1] including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. [ 2 ]
The Therapeutic Index is the quotient of the Toxic Dose and the Effective Dose, not the Lethal Dose. 89.146.16.26 ( talk ) 09:00, 28 September 2009 (UTC) [ reply ] You are confusing it with protective index , which is exactly what you describe, using TD50 instead of LD50.
This is especially useful in the area of psychiatric pharmacy because a lot of drugs used to treat psychiatric illnesses (for example, lithium citrate and clozapine) have a narrow therapeutic window. There is a lot of potential for severe adverse reactions when using certain psychiatric medications, making therapeutic drug monitoring a useful ...
First published in 1941, the book is in its 14th edition (as of 2022), and has the reputation of being the "bible of pharmacology". The readership of this book include physicians of all therapeutic and surgical specialties, clinical pharmacologists, clinical research professionals and pharmacists.