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The area under the effect curve (AUEC) is an integral of the effect of a drug over time, estimated as a previously-established function of concentration. It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing schedule variations than AUC.
The main criticism to the ROC curve described in these studies regards the incorporation of areas with low sensitivity and low specificity (both lower than 0.5) for the calculation of the total area under the curve (AUC)., [19] as described in the plot on the right.
This method was further developed and employed by Archimedes in the 3rd century BC and used to calculate the area of a circle, the surface area and volume of a sphere, area of an ellipse, the area under a parabola, the volume of a segment of a paraboloid of revolution, the volume of a segment of a hyperboloid of revolution, and the area of a ...
In science and engineering, a log–log graph or log–log plot is a two-dimensional graph of numerical data that uses logarithmic scales on both the horizontal and vertical axes. Power functions – relationships of the form y = a x k {\displaystyle y=ax^{k}} – appear as straight lines in a log–log graph, with the exponent corresponding to ...
One can often quickly calculate this using the PV diagram as it is simply the area enclosed by the cycle. [citation needed] Note that in some cases specific volume will be plotted on the x-axis instead of volume, in which case the area under the curve represents work per unit mass of the working fluid (i.e. J/kg). [citation needed]
This probability is given by the integral of this variable's PDF over that range—that is, it is given by the area under the density function but above the horizontal axis and between the lowest and greatest values of the range. The probability density function is nonnegative everywhere, and the area under the entire curve is equal to 1.
The trajectory of a particle (in red) along a curve inside a vector field. Starting from a, the particle traces the path C along the vector field F. The dot product (green line) of its tangent vector (red arrow) and the field vector (blue arrow) defines an area under a curve, which is equivalent to the path's line integral.
Approximating the area under the curve y = x 2 over [0, 2] using the right Riemann sum. Notice that because the function is monotonically increasing, the right Riemann sum will always overestimate the area contributed by each term in the sum (and do so maximally).