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FDPB-based methods calculate the change in the pK a value of an amino acid side chain when that side chain is moved from a hypothetical fully solvated state to its position in the protein. To perform such a calculation, one needs theoretical methods that can calculate the effect of the protein interior on a p K a value, and knowledge of the pKa ...
The value of pK a also depends on molecular structure of the acid in many ways. For example, Pauling proposed two rules: one for successive p K a of polyprotic acids (see Polyprotic acids below), and one to estimate the p K a of oxyacids based on the number of =O and −OH groups (see Factors that affect p K a values below).
pKa prediction; generation of various molecular surfaces (electrostatic potential, electron density, molecular orbitals etc.) prediction of various molecular properties (multipole moments, polarizabilities, vibrational frequencies etc.)
In chemistry and biochemistry, the Henderson–Hasselbalch equation = + ([] []) relates the pH of a chemical solution of a weak acid to the numerical value of the acid dissociation constant, K a, of acid and the ratio of the concentrations, [] [] of the acid and its conjugate base in an equilibrium.
In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase [1] whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
3-Hydroxypropionic acid is of interest as a bio-derived precursor to acrylic acid. [5]The polyester poly(3-hydroxypropionic acid) is a biodegradable polymer. [7] The method combines the high-molecular weight and control aspects of ring-opening polymerization with the commercial availability of the beta hydroxy acid, 3-hydroxypropionic acid which is abbreviated as 3-HP.
Since Tris' pKa is more strongly temperature dependent, its use is not recommended in biochemical applications requiring consistent pH over a range of temperatures. Moreover, the temperature dependance of the pKa (and in turn buffer solution pH) makes pH adjustment difficult. [8] (E.g., the 'room temperature' pH adjustment would not translate ...
Bis-tris methane is an organic tertiary amine with labile protons having a pKa of 6.46 at 25 °C. It is an effective buffer between the pH 5.8 and 7.2. Bis-tris methane binds strongly to Cu and Pb ions as well as, weakly, to Mg, Ca, Mn, Co, Ni, Zn and Cd.