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  2. Pyruvate dehydrogenase complex - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_dehydrogenase_complex

    Pyruvate dehydrogenase complex. Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that converts pyruvate into acetyl-CoA by a process called pyruvate decarboxylation. [1] Acetyl-CoA may then be used in the citric acid cycle to carry out cellular respiration, and this complex links the glycolysis metabolic pathway to the citric ...

  3. Pyruvate dehydrogenase (lipoamide) beta - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_dehydrogenase...

    The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits.

  4. Pyruvate dehydrogenase - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_dehydrogenase

    Pyruvate dehydrogenase is an enzyme that catalyzes the reaction of pyruvate and a lipoamide to give the acetylated dihydrolipoamide and carbon dioxide. The conversion requires the coenzyme thiamine pyrophosphate. Pyruvate dehydrogenase is usually encountered as a component, referred to as E1, of the pyruvate dehydrogenase complex (PDC). PDC ...

  5. File:Pyruvate dehydrogenase phosphorylation sites.png

    en.wikipedia.org/wiki/File:Pyruvate...

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  6. Dihydrolipoyl transacetylase - Wikipedia

    en.wikipedia.org/wiki/Dihydrolipoyl_transacetylase

    Dihydrolipoyl transacetylase (or dihydrolipoamide acetyltransferase) is an enzyme component of the multienzyme pyruvate dehydrogenase complex. The pyruvate dehydrogenase complex is responsible for the pyruvate decarboxylation step that links glycolysis to the citric acid cycle. This involves the transformation of pyruvate from glycolysis into ...

  7. Lipogenesis - Wikipedia

    en.wikipedia.org/wiki/Lipogenesis

    Pyruvate dehydrogenase (PDH), converts pyruvate into acetyl-CoA. Acetyl-CoA carboxylase (ACC), converts acetyl-CoA produced by PDH into malonyl-CoA. Malonyl-CoA provides the two-carbon building blocks that are used to create larger fatty acids. Insulin stimulation of lipogenesis also occurs through the promotion of glucose uptake by adipose ...

  8. Pyruvate decarboxylation - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_decarboxylation

    Pyruvate + NAD + + CoA → Acetyl-CoA + NADH + CO 2. Pyruvate oxidation is the step that connects glycolysis and the Krebs cycle. [4] In glycolysis, a single glucose molecule (6 carbons) is split into 2 pyruvates (3 carbons each). Because of this, the link reaction occurs twice for each glucose molecule to produce a total of 2 acetyl-CoA ...

  9. Branched-chain alpha-keto acid dehydrogenase complex

    en.wikipedia.org/wiki/Branched-chain_alpha-keto...

    This enzyme complex catalyzes the oxidative decarboxylation of branched, short-chain alpha-ketoacids. BCKDC is a member of the mitochondrial α-ketoacid dehydrogenase complex family, which also includes pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, key enzymes that function in the Krebs cycle.

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