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A melanocytic nevus (also known as nevocytic nevus, nevus-cell nevus, and commonly as a mole) [1] [2] is usually a noncancerous condition of pigment-producing skin cells. It is a type of melanocytic tumor that contains nevus cells . [ 2 ]
However, a melanocytic nevus is benign, and melanoma is malignant. Most melanocytic nevi never evolve into a cancer, with the lifetime risk for an individual nevus being 1 in 3000 for men and 1 in 11 000 for women. [5] Moreover, dermatologists have a standardized system for determining whether a skin lesion is suspicious for malignant melanoma.
Melanocytic nevus. Melanocytic nevi can be categorized based on the location of melanocytic cells [2] Junctional: epidermis; Intradermal: dermis; Compound: epidermis and dermis; Atypical (dysplastic) nevus: This type of nevus must be diagnosed based on histological features. Clinically, atypical nevi are characterized by variable pigmentation ...
Inherited dysplastic nevus syndrome is an autosomal dominant hereditary condition. Dysplastic nevi are more likely to undergo malignant transformation when they occur among members of melanoma families. At least one study indicates a cumulative lifetime risk of nearly 100% in individuals who have dysplastic nevi and are members of melanoma ...
Dermal nevus cells can be further classified: type A (epithelioid) dermal nevus cells mature into type B (lymphocytoid) dermal nevus cells which mature further into type C (neuroid) dermal nevus cells, through a process involving downwards migration. [2] Nevus cells are the primary component of a melanocytic nevus. [3]
Giant congenital melanocytic nevus in newborn. Congenital melanocytic nevi may be divided into the following types: [6]: 690–1 Small-sized congenital melanocytic nevus is defined as having a diameter less than 2 cm (0.79 in). [6]: 690 Medium-sized congenital melanocytic nevus is defined as having a diameter more than 2 cm (0.79 in) but less ...
Acral nevi may occur in all ethnic groups, but are more common in dark-skinned people. The acral nevus is a benign skin lesion that can occur at any age, but is generally noticed between 10 and 30 years of age. Both children and adults may be observed with this skin lesion.
A Spitz nevus is a benign skin lesion.A type of melanocytic nevus, it affects the epidermis and dermis. [1]It is also known as an epithelioid and spindle-cell nevus, [2] and misleadingly as a benign juvenile melanoma, [2]: 691 and Spitz's juvenile melanoma [3]).