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Common side effects include abdominal pain, dizziness, swelling, headache, and a rash. [11] Serious side effects may include heart disease, stroke, kidney problems, and stomach ulcers. [11] Use is not recommended in the third trimester of pregnancy. [11] It blocks cyclooxygenase-2 (COX-2) more than it blocks cyclooxygenase-1 (COX-1). [11]
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
There are a few possible side effects linked to taking NSAIDs, including: gastrointestinal problems (such as irritation, ulcers, or bleeding), increased risk of heart attack and stroke, reduced ...
These differential effects are due to the different roles and tissue localisations of each COX isoenzyme. [11] By inhibiting physiological COX activity, NSAIDs may cause deleterious effects on kidney function, [12] and, perhaps as a result of water and sodium retention and decreases in renal blood flow, may lead to heart problems. [13]
But some research has noted rare but serious side effects of once-weekly, 2.4-milligram (mg) semaglutide injections, such as pancreatitis, acute kidney injury, gallbladder issues, and thyroid cancer.
The inhibition of COX-2 is paramount for the anti-inflammatory and analgesic function of the selective COX-2 inhibitor celecoxib. However, with regard to this drug's promise for the therapy of advanced cancers, it is unclear whether the inhibition of COX-2 plays a dominant role, and this has become a controversial and intensely researched issue.