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Several drug or drug candidates feature amidine substituents. Examples include the antiprotozoal imidocarb, the insecticide amitraz, xylamidine, an antagonist at the 5HT2A receptor, [9] and the anthelmintics amidantel and tribendimidine.
1,8-Diazabicyclo[5.4.0]undec-7-ene, or more commonly DBU, is a chemical compound and belongs to the class of amidine compounds. It is used in organic synthesis as a catalyst, a complexing ligand, and a non-nucleophilic base. [3]
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With ammonia or an amine to form an amidine (di-nitriles may form imidines, for instance succinimidine from succinonitrile) [7] With water to form an ester; With hydrogen sulfide to form a thionoester; Commonly, the Pinner salt itself is not isolated, with the reaction being continued to give the desired functional group (orthoester etc.) in ...
As a source of amidine, acetamidine hydrochloride is a precursor to the industrial and laboratory synthesis of many nitrogen compounds.It reacts with β-dicarbonyls to produce substituted pyrimidines, [5] with acetaldehydes to form substituted imidazoles, [6] and with imidates to form substituted triazines.
Some uncommon examples of amides are N-chloroacetamide (H 3 C−C(=O)−NH−Cl) and chloroformamide (Cl−C(=O)−NH 2). Amides are qualified as primary , secondary , and tertiary according to the number of carbon atoms bounded to the nitrogen atom.
Structures of three kinds of amides: an organic amide (carboxamide), a sulfonamide, and a phosphoramide. In chemistry, the term amide (/ ˈ æ m aɪ d / or / ˈ æ m ɪ d / or / ˈ eɪ m aɪ d /) [1] [2] [3] is a compound with the functional group R n E(=O) x NR 2, where x is not zero, E is some element, and each R represents an organic group or hydrogen. [4]
The imine is often generated in situ from an amine and formaldehyde.An example is the reaction of cyclopentadiene with benzylamine to an aza norbornene. [9]The catalytic cycle starts with the reactions of the aromatic amine with formaldehyde to the imine and the reaction of the ketone with proline to the diene.