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By definition, they are temporary biologic dressings which the body will reject within days to a few weeks. They are useful in reducing the bacterial concentration of an open wound, as well as reducing fluid loss. For more extensive tissue loss, a full-thickness skin graft, which includes the entire thickness of the skin, may be necessary.
Artificial skin is a collagen scaffold that induces regeneration of skin in mammals such as humans. The term was used in the late 1970s and early 1980s to describe a new treatment for massive burns. It was later discovered that treatment of deep skin wounds in adult animals and humans with this scaffold induces regeneration of the dermis. [1]
Donor site 8 days after a skin graft. Skin grafting is a surgical procedure where a piece of healthy skin, also known as the donor site, is taken from one body part and transplanted to another, often to cover damaged or missing skin. [12] Before surgery, the location of the donor site would be determined, and patients would undergo anesthesia. [13]
The wound is initially cleaned, debrided and observed, typically 4 or 5 days before closure. The wound is purposely left open. Examples: healing of wounds by use of tissue grafts. If the wound edges are not reapproximated immediately, delayed primary wound healing transpires. This type of healing may be desired in the case of contaminated wounds.
If the wound is severe enough that necrosis has attacked the surrounding skin, a skin graft can help remove the dead cells before replacing them with new, healthy skin. If this is not done ...
Skin grafting – often used to treat skin loss due to a wound, burn, infection, or surgery. In the case of damaged skin, it is removed, and new skin is grafted in its place. Skin grafting can reduce the course of treatment and hospitalization needed, and can also improve function and appearance. There are two types of skin grafts:
The length and angle of each flap are usually the same to avoid mismatched flaps that may be difficult to close. Some possible complications of Z-plasty include flap necrosis, haematoma (blood clot) formation under the flaps, wound infection, trapdoor effect and sloughing (necrosis) of the flap caused by wound tension and inadequate blood supply.
As for larger wounds, autologous split-thickness grafts involving transplantation of the epidermis and partial portion of the dermis are used. [19] More extensive wounds or burns would typically require allografts sourced from cadavers. [19] Artificial skin can also be used in treating serious burns or chronic skin wounds. [20]