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Medium-chain acyl-CoA dehydrogenase deficiency (MCAD deficiency or MCADD) is a disorder of fatty acid oxidation that impairs the body's ability to break down medium-chain fatty acids into acetyl-CoA. The disorder is characterized by hypoglycemia and sudden death without timely intervention, most often brought on by periods of fasting or vomiting.
The Anneewakee Treatment Center was a Douglasville, Georgia, United States, based adolescent treatment center which changed name to the New Annewakee, Inner Harbour Hospital and now Inner Harbour, Ltd (DBA) Inner Harbour for Children and Families, after a major lawsuit by 110 former "patients" for $432M in 1990, represented by attorneys B. Randall Blackwood and Patricia Edelkind.
VLCAD (very long-chain-acyl-dehydrogenase) deficiency is exclusively linked to genetic mutations in DNA. A change of the gene that codes for very long-chain-acyl-CoA-dehydrogenase (VLCAD) results in a deficiency or malfunction of the produced VLCAD enzyme. [7] This mutation occurs on chromosome 17 and can be altered via a variety of pathways. [4]
The facility opened in 1998 as part of the Medical College of Georgia's 10 year master-plan expansion as the MCGHealth Children's Medical Center, and was renamed in 2013. [6] The hospital is among the largest pediatric facilities in the United States .
The Children's Healthcare of Atlanta - Scottish Rite Hospital is a nationally ranked, freestanding, 319-bed, pediatric acute care children's hospital located in Atlanta, Georgia. It is affiliated with the Emory University School of Medicine [ 1 ] and the Morehouse School of Medicine , [ 2 ] as a member of the Children's Healthcare of Atlanta ...
Short-chain acyl-coenzyme A dehydrogenase deficiency affected infants will have vomiting, low blood sugar, a lack of energy , poor feeding, and failure to gain weight and grow. Additional features of this disorder may include poor muscle tone ( hypotonia ), seizures, developmental delays, and microcephaly .