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While the disease does not cause pain directly, pain is a symptom experienced by most people with ALS caused by reduced mobility. [36] Symptoms of lower motor neuron degeneration include muscle weakness and atrophy, muscle cramps, and fleeting twitches of muscles that can be seen under the skin (fasciculations). [24]
Symptoms that affect the sensory and motor systems seem to develop symmetrically. For example, if the right foot is affected, the left foot is affected simultaneously or soon becomes affected. [1] In most cases, the legs are affected first, followed by the arms. The hands usually become involved when the symptoms reach above the ankle. [3]
Micrograph of a muscle biopsy. The diagnosis of polyneuropathy begins with a history (anamnesis) and physical examination to ascertain the pattern of the disease process (such as arms, legs, distal, proximal), if they fluctuate, and what deficits and pain are involved. If pain is a factor, determining where and how long it has been present is ...
What you need to know about the signs and symptoms, causes, and treatment options for the rare neurological disease.
ALS is characterized by stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size. It may begin with weakness in the arms or legs, or with difficulty speaking or swallowing. About half of the people affected develop at least mild difficulties with thinking and behavior and most people experience pain.
As the disease progresses, it causes a gradual loss of muscle function and mobility. Currently, there is no cure for ALS. Treatment focuses on alleviating symptoms, preventing complications, and ...