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Fulton co-developed tretinoin, known by the brand name as Retin-A, with Dr. Albert Kligman. [1] [2] Fulton was also pioneer for his use of new procedures and treatments in dermatology. He is believed to be the first dermatologist to include an aesthetician on the staff of his medical team. [1]
Topical tretinoin is for use only on the skin and should not be applied to eyes or mucosal tissues. Common side effects include skin irritation, redness, swelling, and blistering. [ 6 ] If irritation is a problem, a decrease in the frequency of application to every other or every third night can be considered, and the frequency of application ...
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The basic structure of the hydrophobic retinoid molecule consists of a cyclic end group, a polyene side chain and a polar end group. The conjugated system formed by alternating C=C double bonds in the polyene side chain are responsible for the color of retinoids (typically yellow, orange, or red).
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Retinyl acetate (retinol acetate, vitamin A acetate) is a natural [dubious – discuss] form of vitamin A which is the acetate ester of retinol.It has potential antineoplastic and chemopreventive activities.
The identification of the use of tretinoin along Dr. James E. Fulton and Dr. Gerd Plewig as a treatment for acne and wrinkles was perhaps their best-known contribution to dermatology. Sold as Retin-A, this innovation earned Kligman significant royalties. He was a generous supporter of the department of dermatology at the University of ...
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