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H1 receptors are linked to allergic responses, H2 to gastric acid regulation, H3 to neurotransmitter release modulation, and H4 to immune system function. There are four known histamine receptors: H 1 receptor H1 Receptors: These receptors are primarily located on smooth muscle cells, endothelial cells, and neurons.
The H 1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. This receptor is activated by the biogenic amine histamine . It is expressed in smooth muscles , on vascular endothelial cells , in the heart, and in the central nervous system .
Histamine H 3 receptor: Located in the central nervous system and to a lesser extent peripheral nervous system tissue Autoreceptor and heteroreceptor functions: decreased neurotransmitter release of histamine, acetylcholine, norepinephrine, serotonin. Modulates nociception, gastric acid secretion, and food intake. [23] Histamine H 4 receptor
The gene sequence for H 3 receptors expresses only about 22% and 20% homology with both H 1 and H 2 receptors respectively. There is much interest in the histamine H 3 receptor as a potential therapeutic target because of its involvement in the neuronal mechanism behind many cognitive disorders and especially its location in the central nervous ...
The histamine H 4 receptor has been identified as a vital regulator of the immune system, involved in eosinophil migration, mast cell recruitment, dendritic cell activation, and T cell differentiation. The discovery of this receptor has brought it to increasing attention for its therapeutic use in inflammatory diseases such as allergy, asthma ...
H 2 receptors are a type of histamine receptor found in many parts of the anatomy of humans and other animals. They are positively coupled to adenylate cyclase via G s alpha subunit. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. [5] PKA functions to phosphorylate certain proteins, affecting their ...
Pages in category "Histamine receptors" The following 5 pages are in this category, out of 5 total. This list may not reflect recent changes. H. Histamine H1 receptor;
Histaminergic means "working on the histamine system", and histaminic means "related to histamine". [1] A histaminergic agent (or drug) is a chemical which functions to directly modulate the histamine system in the body or brain. Examples include histamine receptor agonists and histamine receptor antagonists (or antihistamines).