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[17] iPS cells derived from DKC patients with a heterozygous mutation on the TERT gene display a 50% reduction in telomerase activity compared to wild type iPS cells. [38] Conversely, mutations on the TERC gene (RNA portion of telomerase complex) can be overcome by up-regulation due to reprogramming as long as the hTERT gene is intact and ...
The core domain of TERC contains the RNA template from which TERT synthesizes TTAGGG telomeric repeats. [10] Unlike in other RNPs, in telomerase, the protein TERT is catalytic while the lncRNA TERC is structural, rather than acting as a ribozyme. [14] The core region of TERC and TERT are sufficient to reconstitute catalytic telomerase activity ...
The genes of telomerase subunits, which include TERT, [16] TERC, [17] DKC1 [18] and TEP1, [19] are located on different chromosomes. The human TERT gene (hTERT) is translated into a protein of 1132 amino acids. [20] TERT polypeptide folds with (and carries) TERC, a non-coding RNA (451 nucleotides long). TERT has a 'mitten' structure that allows ...
Telomeric repeat–containing RNA (TERRA) is a long non-coding RNA transcribed from telomeres - repetitive nucleotide regions found on the ends of chromosomes that function to protect DNA from deterioration or fusion with neighboring chromosomes. TERRA has been shown to be ubiquitously expressed in almost all cell types containing linear ...
An image of multiple chromosomes, taken from many cells. Plant genetics is the study of genes, genetic variation, and heredity specifically in plants. [1] [2] It is generally considered a field of biology and botany, but intersects frequently with many other life sciences and is strongly linked with the study of information systems.
In A. thaliana, function A is mainly represented by two genes APETALA1 (AP1) and APETALA2 (AP2) [16] AP1 is a MADS-box type gene, while AP2 belongs to the family of genes that contains AP2, which it gives its name to and which consists of transcription factors that are only found in plants. [17]
The epigenetics of plant growth and development refers to the heritable changes in gene expression that occur without alterations to the DNA sequence, influencing processes in plants such as seed germination, flowering, and stress responses through mechanisms like DNA methylation, histone modification, and chromatin remodeling.
Early diverging land plant: Ceratodon purpureus: Bryophytes: Early diverging land plant: Fontinalis antipyretica (greater water-moss) Bryophytes: Aquatic moss 385.2 Mbp 16,538 BGI: 2020 [1] BGISEQ-500 & 10X, scaffold N50 45.8 Kbp Marchantia polymorpha: Bryophytes: Early diverging land plant 225.8 Mb 19,138 2017 [2] Physcomitrella patens ssp ...