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Stabilizing selection is the most common form of nonlinear selection (non-directional) in humans. [13] There are few examples of genes with direct evidence of stabilizing selection in humans. However, most quantitative traits (height, birthweight, schizophrenia) are thought to be under stabilizing selection, due to their polygenicity and the ...
In natural selection, negative selection [1] or purifying selection is the selective removal of alleles that are deleterious. This can result in stabilising selection through the purging of deleterious genetic polymorphisms that arise through random mutations.
The first and most common function to estimate fitness of a trait is linear ω =α +βz, which represents directional selection. [1] [10] The slope of the linear regression line (β) is the selection gradient, ω is the fitness of a trait value z, and α is the y-intercept of the fitness function.
The K a /K s ratio is used to infer the direction and magnitude of natural selection acting on protein coding genes. A ratio greater than 1 implies positive or Darwinian selection (driving change); less than 1 implies purifying or stabilizing selection (acting against change); and a ratio of exactly 1 indicates neutral (i.e. no) selection.
Middle (Graph 2) represents stabilizing selection with the moderate trait favored. Bottom (Graph 3) represents disruptive selection with both extremes being favored. In population genetics , directional selection is a type of natural selection in which one extreme phenotype is favored over both the other extreme and moderate phenotypes.
Disruptive selection is a specific type of natural selection that actively selects against the intermediate in a population, favoring both extremes of the spectrum. Disruptive selection is inferred to oftentimes lead to sympatric speciation through a phyletic gradualism mode of evolution. Disruptive selection can be caused or influenced by ...
Thus, where stabilizing selection acts because of the particular niche that is occupied, mechanical and physico-chemical constraints act in a more general manner. For example, the acceleration caused by gravity places constraints on the minimum bone density and strength for an animal of a particular size.
Selection can be divided into three classes, on the basis of its effect on allele frequencies: directional, stabilizing, and disruptive selection. [103] Directional selection occurs when an allele has a greater fitness than others, so that it increases in frequency, gaining an increasing share in the population.