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Clonazepam, a benzodiazepine is used to treat many forms of parasomnia. [77] Rapid eye movement behavior disorder responds well to low doses of clonazepam. [78] [79] Restless legs syndrome can be treated using clonazepam as a third line treatment option as the use of clonazepam is still investigational. [80] [81]
Clobazam, sold under the brand names Frisium, Onfi and others, is a benzodiazepine class medication that was patented in 1968. [3] Clobazam was first synthesized in 1966 and first published in 1969.
IC 50 / pIC 50 values represent binding affinity only and do not reflect efficacy or pharmacokinetics, and some compounds listed are GABA A antagonists rather than agonists (e.g. flumazenil). Low IC 50 or high pIC 50 values indicate tighter binding (pIC 50 of 8.0 = IC 50 of 10nM, pIC 50 of 9.0 = IC 50 of 1nM, etc.)
Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
Clonazepam may also decrease memory formation. [11] Long-term use may result in tolerance, dependence, and life-threatening withdrawal symptoms if stopped abruptly. [11] [14] Dependence occurs in one-third of people who take benzodiazepines for longer than four weeks. [10] The risk of suicide increases, particularly in people who are already ...
Celexa – an antidepressant of the SSRI class; Centrax – an anti-anxiety agent; Clozaril – atypical antipsychotic used to treat resistant schizophrenia; Concerta (methylphenidate) – an extended release form of methylphenidate
In photos provided by Pennsylvania-based company it shows the potential mislabeling of a package of the Clonazepam tablets, USP 2 mg lot 550176501 with a carton description and NDC code of ...
Clonazolam's effects are similar to other benzodiazepines, such as anxiolysis, disinhibition, lethargy, muscle relaxation, and euphoria. [2] [8] While no dose of clonazolam is considered "safe" due to its lack of research and extreme potency, doses higher than 0.5 mg can cause benzodiazepine overdose in some individuals.